Blar i forfatter "Jensen, Einar"

Viser treff 1-5 av 5

    • Airborne exposure to gaseous and particle-associated organic substances in resin-based dental materials during restorative procedures 

      Nilsen, Bo Wold; Jensen, Einar; Õrtengren, Ulf; Bang, Berit; Michelsen, Vibeke Barman (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07-16)
      Dental composite dust has been shown to act as a vehicle for methacrylates in vivo/in vitro. The objective of this study was to assess airborne exposure of dental personnel to gaseous and particle‐associated organic constituents from resin‐based dental materials in a simulated clinic. Sampling of total aerosol fractions and gaseous substances was performed by dental students carrying particle filters ...

    • Dose- and time-dependent effects of triethylene glycol dimethacrylate on the proteome of human THP-1 monocytes 

      Nilsen, Bo Wold; Simon-Santamaria, Jaione; Ørtengren, Ulf Thore; Jensen, Einar; Bruun, Jack-Ansgar; Michelsen, Vibeke Barman; Sørensen, Karen Kristine (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-27)
      Triethylene glycol dimethacrylate (TEGDMA) is commonly used in polymer resinbased dental materials. This study investigated the molecular mechanisms of TEGDMA toxicity by identifying its time- and dose-dependent effects on the proteome of human THP-1 monocytes. The effects of different concentrations (0.07– 5 mM) and exposure times (0–72 h) of TEGDMA on cell viability, proliferation, and morphology ...

    • Lipidomics in ulcerative colitis reveal alteration in mucosal lipid composition associated with the disease state 

      Diab, Joseph; Hansen, Terkel; Goll, Rasmus; Stenlund, Hans; Ahnlund, Maria; Jensen, Einar; Moritz, Thomas; Florholmen, Jon; Forsdahl, Guro (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-11)
      <p><i>Background - </i>The onset of ulcerative colitis (UC) is associated with alterations in lipid metabolism and a disruption of the balance between pro- and anti-inflammatory molecules. Only a few studies describe the mucosal lipid biosignatures during active UC. Moreover, the dynamics of lipid metabolism in the remission state is poorly defined. Therefore, this study aims to characterize mucosal ...

    • Mucosal Metabolomic Profiling and Pathway Analysis Reveal the Metabolic Signature of Ulcerative Colitis 

      Diab, Joseph; Hansen, Terkel; Goll, Rasmus; Stenlund, Hans; Jensen, Einar; Moritz, Thomas; Florholmen, Jon; Forsdahl, Guro (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-27)
      The onset of ulcerative colitis (UC) is characterized by a dysregulated mucosal immune response triggered by several genetic and environmental factors in the context of host–microbe interaction. This complexity makes UC ideal for metabolomic studies to unravel the disease pathobiology and to improve the patient stratification strategies. This study aims to explore the mucosal metabolomic profile in ...

    • A Quantitative Analysis of Colonic Mucosal Oxylipins and Endocannabinoids in Treatment-Naïve and Deep Remission Ulcerative Colitis Patients and the Potential Link With Cytokine Gene Expression 

      Diab, Joseph; Al-Mahdi, Rania; Gouveia, Sandra; Hansen, Terkel; Jensen, Einar; Goll, Rasmus; Moritz, Thomas; Florholmen, Jon; Forsdahl, Guro (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-22)
      <p><i>Background</i> - The bioactive metabolites of omega 3 and omega 6 polyunsaturated fatty acids (ω-3 and ω-6) are known as oxylipins and endocannabinoids (eCBs). These lipid metabolites are involved in prompting and resolving the inflammatory response that leads to the onset of inflammatory bowel disease (IBD). This study aims to quantify these bioactive lipids in the colonic mucosa and to ...